• Glycerol In this study we first demonstrated that the CD

  2018-11-08

  

  In this study, we first demonstrated that the CD44+ population isolated from the HCT-15 human colon cancer cell line not only exhibited multiple in vitro features of CSCs but also showed higher in vivo tumorigenicity. In accordance, knocking down CD44 expression in HCT-15 Glycerol resulted in redu

• The myocardium lacks the basal apical orientation typical of

  2018-11-08

  

  The myocardium lacks the basal–apical orientation typical of epithelial organs making it difficult to delineate the precise localization of CSC niches. The epicardial lining has been employed to define anatomically several classes of niches in the adult heart (Castaldo et al., 2008; Di Meglio et al.

• br Materials methods The derivation and culturing

  2018-11-08

  

  Materials & methods The derivation and culturing conditions of hAT-MSCs are thoroughly described in Supplementary Materials and methods section, while details regarding hiPS lines generation and validation are described elsewhere (Kyrkou et al., in press). Results Discussion Human AT-MSCs

• Recently using the cynomolgus macaque PGCs were first

  2018-11-08

  

  Recently using the cynomolgus macaque, PGCs were first identified in the amnion of the peri-implantation embryo at day 11 (Sasaki et al., 2016). The amnion develops coincident with the generation of the amniotic cavity and formation of the bilaminar embryo (Fig. 1, arrow points to amnion cells in th

• Human leukocyte class I HLA I molecules are critical for

  2018-11-08

  

  Human leukocyte class I (HLA-I) molecules are critical for antigen presentation to CD8+ cytotoxic T-lymphocyte (Garrido et al., 1993), and are understood to be widely expressed on the cell surface of all normal human tissues (Daar et al., 1984). However, HLA-I expression has been reported to be abse

• br Experimental Procedures br Author

  2018-11-08

  

  Experimental Procedures Author Contributions Acknowledgments We are grateful to Y. Okada (Aichi Medical University) and T. Matsumoto (Ajinomoto) for technical assistance, helpful advice, and discussions; T. Abe (Keio University) for statistical analysis; and all members of the H.O. laborato

• br Introduction Cardiac and skeletal myogenesis both generat

  2018-11-08

  

  Introduction Cardiac and skeletal myogenesis both generate striated muscle, but are traditionally thought of as two separate processes with distinct developmental anlagen. However, recent work suggests the existence of at least one bipotent anlage for cardiac and skeletal muscle: the common proge

• PD173074 br Results and Discussion br Experimental Procedure

  2018-11-08

  

  Results and Discussion Experimental Procedures Author Contributions Acknowledgments We would like to thank Hospital de São João for bone marrow samples and buffy coats. This work had the financial support of FCT/MEC through National Funds and, when applicable, co-financed by the FEDER th

• Our data have additional implications of applied

  2018-11-08

  

  Our data have additional implications of applied nature. Prospective isolation of putative “MSCs” from different tissues, based on the use of the minimal effective surface phenotype CD34−/CD45−/CD146+ (Sacchetti et al., 2007), leads to isolation of committed tissue-specific progenitors, not of broad

• The experimental design of this model provides

  2018-11-08

  

  The experimental design of this model provides several differences to standard 2D culture: EHTs are anchored between two flexible silicone posts, which generate a preload, and EHTs perform auxotonic contractile work (the physiological form of cardiac contraction) against elastic posts. This results

• Each method of KNO production has its

  2018-11-07

  

  Each method of KNO3 production has its advantages and disadvantages and the choice of one method over another is influenced by the availability of raw materials, purity of KNO3, waste treatment and cost of production (Jurišová et al., 2013). In Freilich (2005) it was reported that sodium chloride is

• hydralazine hcl Average hours of sleep per day was h consist

  2018-11-07

  

  Average hours of sleep per day was 7.9±1.7h, consistent with the suggestion of the US National Sleep Foundation (between 7 and 9h) and what has been reported in Latin America in 1776 individuals from 18 to 70 years of age from three of the largest cities where an average of 5.8h of sleep per day was

• Para el segundo juego mixto obtuvimos

  2018-11-07

  

  Para el segundo juego mixto obtuvimos que el promedio del bando con memoria 5 fue de -259.733 en el tiempo 8,192 de la simulación, mientras que la del bando con memoria 7 fue de -550.244, lo cual se puede apreciar en la gráfica 15. De acuerdo caspase pathway esto, y como se puede apreciar en la gráf

• En este n mero de

  2018-11-07

  

  En este número de se presentan temas de relevancia para nuestra economía. Se bordan desde distintas perspectivas para mostrar una serie de aspectos que inceden en su marcha. En el primer artículo se presenta un análisis econométrico por parte de Manuel Ontiveros sobre la determinación del sobrepeso

• Progress toward the treatment of three major parasitic

  2018-11-07

  

  Progress toward the treatment of three major parasitic diseases (sleeping sickness, Chagas disease, and leishmaniasis) was recently demonstrated in an article published online last month in the journal (August 8, 2016). Collectively, these three diseases affect 20 million people per year, resulting

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